2021 Lexus RX 350 problems, recalls, safety rating, MPG & value

Q: Does the 2021 Lexus RX 350 have any safety recalls?

NHTSA lists 1 recall campaign for the 2021 Lexus RX 350. Whether an individual car still needs a recall repair depends on its VIN — check it on NHTSA.gov or ask a franchised dealer. Recall repairs are free.

Q: What gas mileage does the 2021 Lexus RX 350 get?

The 2021 Lexus RX 350 has a U.S. EPA estimate of 23 mpg combined (20 city / 27 highway).

2021 Lexus RX 350 at a glance

Safety recalls1

Owner complaints71

Combined23 mpg

Free: that car's specs and build sheet, model-year recall campaigns and a fair price.

2021 Lexus RX 350 recalls 1

Fuel System, Gasoline:storage:tank Assembly:filler Pipe And Cap NHTSA Campaign #21V043000 · manufacturer #21LA01 · 03/02/2021

Toyota Motor Engineering & Manufacturing (Lexus) is recalling certain 2019 Lexus RX350 and 2021 RX350 vehicles. The transport hook may not have been removed prior to sale. As such, these vehicles fail to comply with the requirements of Federal Motor Vehicle Safety Standard number 301, "Fuel System Integrity."

Fix: Lexus will notify owners, and dealers will inspect and, as necessary, remove the rear transport hook, free of charge. The recall began April 1, 2021. Owners may contact Lexus customer service at 1-800-331-4331. Lexus' number for this recall is 21LA01.

Source: U.S. NHTSA, checked 7 Oct 2026. A campaign covers the model year; to see whether a particular car still needs the repair, check its VIN on NHTSA.gov or ask a franchised dealer.

2021 Lexus RX 350 common problems

The most-reported problem areas across all 71 owner complaints filed with NHTSA — and what to check before you buy.

Air Bags

Confirm the airbag light turns on then off at startup — if it stays lit there's a fault (costly, and a safety risk). Check for signs of prior deployment.

Structure

Inspect for rust, fresh undercoating, mismatched paint, uneven panel gaps and any sign of prior collision or frame repair.

Electrical System

Test every electrical feature: windows, locks, infotainment, charging and all lights. Watch for flickering, dead accessories or warning lights.

Service Brakes

Brakes should feel firm and quiet — no grinding, pulsing or pulling. Check for an ABS light and uneven pad/rotor wear.

Forward Collision Avoidance

Have a trusted mechanic inspect this system as part of a pre-purchase inspection.

Seat Belts

Check that every belt latches, retracts and locks under a sharp tug, and that none are frayed.

2021 Lexus RX 350 MPG & running costs

Combined23 mpg

City20 mpg

Highway27 mpg

Est. annual fuel cost$2,900

EPA size classSmall Sport Utility Vehicle 2WD

TransmissionAutomatic (S8)

5-yr fuel cost vs average new car$2,500 more

Source: U.S. EPA / DOE fueleconomy.gov.

Estimated 5-year cost to own

A rough guide to what running a 2021 Lexus RX 350 costs over five years and 75,000 miles.

Fuel (5 yrs)$14,500

Fuel only$14,500

Per mile$0.19

How this is estimated: fuel is the U.S. EPA annual cost at 15,000 miles a year. There aren't enough comparable listings to estimate depreciation for this model, so it is left out. Not included: insurance, maintenance, repairs, taxes, registration and finance costs. Treat it as a comparison guide, not a quote.

2021 Lexus RX 350 vehicles on record

Other Lexus RX 350 model years

2021 Lexus RX 350 — frequently asked questions

Does the 2021 Lexus RX 350 have any safety recalls?

NHTSA lists 1 recall campaign for the 2021 Lexus RX 350. Whether an individual car still needs a recall repair depends on its VIN — check it on NHTSA.gov or ask a franchised dealer. Recall repairs are free.

What are the most common problems with the 2021 Lexus RX 350?

Across all 71 owner complaints filed with NHTSA, the most-reported problem areas are air bags, structure, electrical system.

What gas mileage does the 2021 Lexus RX 350 get?

The 2021 Lexus RX 350 has a U.S. EPA estimate of 23 mpg combined (20 city / 27 highway).

Sources: NHTSA (recalls, complaints, crash tests), U.S. EPA (fuel economy). Vehicle data only — CarLogs never shows owner information.