Model year guide

2021 Mercedes-benz S 580 4MATIC

Recalls, most-reported problems, crash-test ratings, fuel economy and what a 2021 Mercedes-benz S 580 4MATIC is worth — from official NHTSA and EPA data. 10 on record.

2021 Mercedes-benz S 580 4MATIC at a glance

Safety recallsNone
Combined20 mpg

Included: that car's specs and build sheet, model-year recall campaigns and a fair price.

2021 Mercedes-benz S 580 4MATIC recalls 0

No NHTSA safety-recall campaigns are on record for the 2021 Mercedes-benz S 580 4MATIC.

Source: U.S. NHTSA, checked 11 Oct 2026. A campaign covers the model year; to see whether a particular car still needs the repair, check its VIN on NHTSA.gov or ask a franchised dealer.

2021 Mercedes-benz S 580 4MATIC MPG & running costs

Combined20 mpg
City17 mpg
Highway25 mpg
Est. annual fuel cost$4,100
EPA size classLarge Cars
TransmissionAutomatic 9-spd
Forced inductionTurbocharged
Engine start-stopYes
Passenger volume107 cu ft
Cargo volume14 cu ft
5-yr fuel cost vs average new car$8,500 more

Source: U.S. EPA / DOE fueleconomy.gov.

Estimated 5-year cost to own

A rough guide to what running a 2021 Mercedes-benz S 580 4MATIC costs over five years and 75,000 miles.

Fuel (5 yrs)$20,500
Fuel only$20,500
Per mile$0.27

How this is estimated: fuel is the U.S. EPA annual cost at 15,000 miles a year. There aren't enough comparable listings to estimate depreciation for this model, so it is left out. Not included: insurance, maintenance, repairs, taxes, registration and finance costs. Treat it as a comparison guide, not a quote.

2021 Mercedes-benz S 580 4MATIC vehicles on record

Other Mercedes-benz S 580 4MATIC model years

2021 Mercedes-benz S 580 4MATIC — frequently asked questions

Does the 2021 Mercedes-benz S 580 4MATIC have any safety recalls?

NHTSA lists no safety-recall campaigns for the 2021 Mercedes-benz S 580 4MATIC. Whether an individual car still needs a recall repair depends on its VIN — check it on NHTSA.gov or ask a franchised dealer. Recall repairs are done at no charge.

What gas mileage does the 2021 Mercedes-benz S 580 4MATIC get?

The 2021 Mercedes-benz S 580 4MATIC has a U.S. EPA estimate of 20 mpg combined (17 city / 25 highway).

Sources: NHTSA (recalls, complaints, crash tests), U.S. EPA (fuel economy). Vehicle data only — CarLogs never shows owner information.